Bioactive Compounds to Treat or Prevent Neurodegenerative Diseases
Case Number: 15-103
Applications: Therapeutics to prevent or reduce the cerebral damage after an ischemic stroke
Worldwide mortality and disability rates due to cerebral ischemia (stroke) are significant, but therapeutic options continue to be limited. The only pharmacological treatment available following a stroke is thrombolytic therapy (tissue plasminogen activator or tPA), which can only be used if patients present themselves to a hospital within four hours of onset, which represents only 4% of patients. After four hours, the risks outweigh the benefits of tPA treatment. There is a need for additional pharmaceutical treatments to lessen cerebral damage immediately following an acute stroke and to expand the 4-hour therapeutic window for tPA treatment. These bioactive compounds have the potential to reduce cerebral damage following stroke and expand the therapeutic window of tPA.
UPEI -100, UPEI -200 and UPEI- 300 are synthetic combinations of naturally-occurring bioactive compounds that are known to have potent antioxidant effects. All three formulations contain lipoic acid combined with another compound. These new compounds have been tested in rat models of reperfusion-injury following ischemia and demonstrated significant protection against cerebral damage. The results also indicate that if the compounds are taken with tPA following a stroke, then it may expand the therapeutic window for tPA therapy by 2 to 3 hours. Screening studies indicate that the efficacy of the synthetically combined compounds is significantly improved compared to taking the two separate compounds in combination. These compounds would be most beneficial if they are used in combination with tPA treatement, however, they can also potentially be used as part of a dietary supplement regiment to prevent stroke.
Significant dose reduction (10 to 1000 fold) compared to the individual compounds, which results in fewer side effects.
Evidence in the rat model that these compounds extend the therapeutic window for typical post-thrombotic stroke therapy.
Stage of Development: The three compounds have been tested in a validated rat model of ischemia-reperfusion injury (stroke).
UPEI-100: US patent has been issued (US 2014/0315989 A1)
UPEI-200: A PCT Application has been filed (PCT/CA2014/051259)
UPEI-300: A PCT Application has been filed (PCT/CA2014/051261)
Opportunity: Licensing and/or Collaborative R&D
Connell B.J, Saleh, M.C., Khan, B.V., Rajagopal, D., and Saleh, T.M. UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion. Am. J. Physiol., (Reg, Int., Comp), 302:R886-R895, 2012.
Monique C. Saleh, Barry J. Connell, Desikan Rajagopal, Bobby V. Khan, Alaa S. Abd-El-Aziz, Inan Kucukkaya and Tarek M. Saleh. Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion. PLoS One. 2014 Jan 31;9(1):e87865. doi: 10.1371/journal.pone.0087865.
Barry J. Connell, Monique C Saleh, Inan Kucukkaya, Alaa S. Abd-El-Aziz, Bobby V. Khan and Tarek M Saleh. UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in a rat model of ischemia/reperfusion. Neurosci Lett., 561:151-155, 2014.View BioActive Compounds to Treat or Prevent Neurodegenerative Diseases 15-103 pdf